Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 7661-33-8, is researched, Molecular C10H10ClNO, about Efficient Synthesis of N-Substituted 2,4-Azepandione Ring System as an Active Intermediate for Heterocyclic Syntheses, the main research direction is azepandione preparation; butanoate acetylarylamino ethyl cyclization.SDS of cas: 7661-33-8.
An improved efficient synthesis for 2,4-azepandiones I [R = H, CH3, Cl; R1 = H, CO2CH3] could be achieved by a careful control of the reaction conditions to cyclize Et 4-(N-acetylarylamino)butanoates 4-R-2-R1C6H3N[(CH2)3CO2CH2CH3]C(O)CH3, resp. Et 4-arylamino butanoates 4-R-2-R1C6H3NH(CH2)3C(O)2CH2CH3 was prepared by stirring the Et 4-bromobutanoate and substituted anilines 4-R-2-R1C6H3NH2 at room temperature Then, they were acetylated with acetyl chloride and triethylamine under the conditions that avoid the formation of 2-pyrrolidinone derivatives II. Due to the rapid decomposition of Et 4-(N-acetylarylamino)butanoates to Et 4-arylaminobutanoates, the reaction mixture was directly transferred without workup to the next cyclization step. The azepandione synthesis was favored by using a weak base at low temperature, where it was in a competition with the other modes of ring closure. The structures of the new compounds were supported by correct anal. and spectral data.
If you want to learn more about this compound(1-(4-Chlorophenyl)pyrrolidin-2-one)SDS of cas: 7661-33-8, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7661-33-8).
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts