Reference of 39590-81-3, Adding some certain compound to certain chemical reactions, such as: 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane,molecular formula is C5H10O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39590-81-3.
General procedure: The diol (48 mmol, 1 eq) wasdissolved into DMF (120 mL) under argon. At 0C NaH (1.1 eq, 60% in mineral oil) was added inone portion and the mixture was stirred at 0C during 45 min. BnBr (0.97 eq) was added dropwise,the mixture was allowed to warm at room temperature and stirred overnight. The reaction wasquenched with saturated NH4Cl solution (20 mL) and then diluted with water. The crude mixturewas extracted with Et2O and the organic layer was washed with brine, dried over anhydrous MgSO4,filtered and concentrated in vacuo. Benzylated compound was then purified by flashchromatography on silica gel.
According to the analysis of related databases, 39590-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Chalopin, Thibaut; Jebali, Khaoula; Gaulon-Nourry, Catherine; Denes, Fabrice; Lebreton, Jacques; Mathe-Allainmat, Monique; Tetrahedron; vol. 72; 2; (2016); p. 318 – 327;,
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