The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 57371-44-5
To a solution ofpyridinium chlorochromate (2.4 g, 11.03 mmol) in dichloromethane (20 mL), O-protectedalcohol 3 (3.0 g, 11.03 mmol) in dichloromethane (20 mL) was added dropwiseusing pressure equalizing additional funnel with constant stirring (magnetic spin bar).The reaction mixture was then heated at reflux. After the completion of the reaction (1 hr)as monitored by tlc for disappearance of O-protected alcohol 3 (eluent: petroleum ether60-80C and EtOAc in 6:4 ratio, Rf D 0.3), silica gel (5 g, 200-400 mesh) was added tothe mixture and dichloromethane was evaporated under vacuum to afford a crude productadsorbed on the gel. It was purified by column chromatography over silica gel (100-200 mesh) using petroleum ether (60-80C) and EtOAc mixtures (95:5 to 80:20) as eluent.The pure product (2.52 g, 85%) was obtained as a white powder, mp. 64-66C; lit.3664-65C; 1H NMR (500 MHz, CDCl3): d 9.84 (s, 1H), 7.45 (d, 2H, J D 7.5), 7.38 (t, 2H,J D 7.4), 7.31 (t, 2H, J D 7.3), 5.14 (s, 2H), 3.90 (s, 3H), 2.91 (t, 2H, J D 7.5), 2.77 (t,2H, J D 7.4); 13C NMR (125 MHz, CDCl3): d 201.4, 149.47, 146.44, 137.01, 133.31,128.20, 127.47, 126.96, 119.83, 114.17, 112.03, 70.93, 55.72, 45.12, 27.46; Mass (ESI) :[MCCNa] for C17H18O3Na, Calcd: 293.1154. Found: 293.0597.Anal. Calcd for C17H18O3: C, 75.53; H, 6.71. Found: C, 75.59; H, 6.72.
With the rapid development of chemical substances, we look forward to future research findings about 57371-44-5.
Reference:
Article; Kumar, N. Vijendra; Kumar, S. C. Santosh; Srinivas; Bettadaiah; Organic Preparations and Procedures International; vol. 47; 6; (2015); p. 443 – 448;,
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