Analyzing the synthesis route of 54410-90-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 54410-90-1, 4-Pentylcyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C11H22O, blongs to alcohols-buliding-blocks compound. Computed Properties of C11H22O

Step 2:2L four bottles of the first step to add 200.8g (1179.0mmol, 1.0eq), 800.0 g of dichloroethane, 131.2 g (1279.0 mmol, 1.1 eq) of triethylamine, 14.4 g (117.8 mmol, 0.1 eq) of 4-dimethylaminopyridine,Into the ice machine cooling to -5 ~ 0 stand.A solution of 148.6 g (1297.0 mmol, 1.1 eq) of methanesulfonyl chloride and 200.8 g of dichloroethane was added dropwise over 1.5 h, and the dropping temperature was controlled at -5 to 5 C,Followed by 0 ~ 5 insulation stirring 1.0h.Add water 600g quenching reaction, then stop the cooling, the kettle temperature to room temperature, stirring 0.5h, standing for 0.5h, divided into an oil layer 1268.0g, the water back to the kettle by adding dichloroethane 200.0g secondary extraction, stirring 0.5 h, standing for 0.5h, separate the secondary reservoir 188.7g.Combined with a secondary oil layer, add water 400.0g washing, stirring 0.5h, standing for 0.5h, separated from the oil layer, desolvation, the use of ethanol to get 260.0g two-step product, the content of> 98%, yield 88% Cis – trans isomer ratio 56/44.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Dai Yao; Liang Quande; Zhao Danyang; Liu Lingling; Wang Weixin; Wang Rongliang; (5 pag.)CN106916089; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts