In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5617-32-3, name is 3,6,9,12,15,18-Hexaoxaicosane-1,20-diol, the common compound, a new synthetic route is introduced below. SDS of cas: 5617-32-3
General procedure: (Using the synthesis of macrocyclic sulfate 6a as an example). To a stirring solution of tetra(ethylene glycol) 5a (40.0 g, 205.95 mmol), triethylamine (100.73 g, 988.56 mmol), and DMAP (1.26 g, 10.30 mmol) in CH2Cl2 (3 L) at 0 °C was slowly added a solution of SOCl2 (50.30 g, 411.90 mmol, in 50 mL CH2Cl2). After the addition, the stirring mixture was warmed to 25 °C and monitored with TLC until the complete consumption of tetra(ethylene glycol). The reaction was quenched with 1.5 L water. The organic layer was collected, filtrated through a pad of silica gel, and concentrated under vacuum to provide the macrocyclic sulfite intermediate as brownish oil which was used directly in the next step. To the solution of macrocyclic sulfite in a mixture of CH2Cl2 (200 mL), CH3CN (200 mL), and water (300 mL) at 0 °C was added NaIO4 (52.86 g, 247.14 mmol) and RuCl3?3H2O (0.27 g, 1.03 mmol). The stirring mixture was gradually warmed to 25 °C and monitored with TLC. Upon complete consumption of the macrocyclic sulfite, the reaction mixture was filtered through a pad of Celite. Organic layer was collected, washed with brine, concentrated under vacuum, and recrystallized in methanol at -20 °C to afford the macrocyclic sulfate 6a as clear crystal (25.14 g, 47percent yield).
The synthetic route of 5617-32-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Deng, Tao; Mao, Xianglan; Xiao, Yan; Yang, Zhigang; Zheng, Xing; Jiang, Zhong-Xing; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 581 – 584;,
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