Related Products of 1875-89-4 , The common heterocyclic compound, 1875-89-4, name is 2-(m-Tolyl)ethanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 306: 2-[1-(4-Chlorophenylsulfonyl)-3-(3-methylphenyl)propyl]-1,4-difluorobenzene In a similar manner to Example 304 except for the use of 2-(3-methylphenyl)ethanol (90.0 mul, 0.661 mmol), the title compound (115 mg, 0.273 mmol, 83percent) was obtained as colorless plate crystals.1H-NMR (400 MHz, CDCl3) delta: 2.29(3H,s), 2.35-2.48(2H,m), 2.56-2.64(1H,m), 2.68-2.77(1H,m), 4.46-4.49(1H,m), 6.83-6.88(3H,m), 6.97-7.03(2H,m), 7.14(1H,t,J=7.8Hz), 7.26(1H,ddd,J=8.7,5.4,3.3Hz), 7.36(2H,d,J=8.6Hz), 7.49(2H,d,J=8.6Hz). IR (ATR) cm-1: 3072, 2969, 1581, 1496, 1475, 1423, 1394, 1319, 1276, 1211, 1147, 1081, 1012. mp: 87-88°C. MS m/z: 421 (M++H).Anal. calcd for C22H19ClF2O2S: C, 62.78; H, 4.55; Cl, 8.42; F, 9.03; S, 7.62. Found: C, 62.58; H, 4.60; Cl, 8.49; F, 9.21; S, 7.77.
The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
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