The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 59012-91-8
Preparation of 5: A 100 G reactor containing the solution of compound 4 is charged with N-methylpyrrolidine (9.5 kg; 2.0 eq dissolved in 23 kg of dichloromethane). After 10 minutes, compound 4a (14.0 kg; 1.2 eq) is added, followed by 1,8-diazabicyclo[5.4.0]undec-7-ene (10.2 kg; 1.2 eq in 23 kg dichloromethane). The batch is warmed to 20 C. Upon reaction completion (1-9 hours), the solution is diluted with 327 kg of dichloromethane and charged to a 200 G reactor containing pH 4.5 phosphate buffer (334 kg of 1 M KH2PO4). The batch is agitated for 30 minutes, and the layers are separated. The lower organic layer is washed once more with pH 4.5 phosphate buffer (111 kg of 1 M KH2PO4), then once with brine (212 kg of 2.5% NaCl/water (w:w)). The resulting organic solution is distilled at <35 C. until Karl Fischer analysis of the batch shows <0.05% water. This solution is used directly in the preparation of compound 1f.
With the rapid development of chemical substances, we look forward to future research findings about 59012-91-8.
Reference:
Patent; AVI BIOPHARMA, INC.; US2009/131624; (2009); A1;,
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