Synthetic Route of 431-23-2 ,Some common heterocyclic compound, 431-23-2, molecular formula is C4H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 3,3,3-trifluoro-2-methylpropan-1-ol (800 mg, 6.25 mmol) in DCM (20mL) was added triethylamine (950 mg, 9.39 mmol). The mixture was cooled to -20 oc andtrifluoromethanesulfonic anhydride (2.20 g, 7.70 mmol) was added. The mixture was stirred at0 oc overnight. The mixture was diluted with DCM (50 mL), washed with 1 M HCl aqueoussolution (50 mLx 2). The separated organic layer was dried over anhydrous Na2S04, and thenconcentrated in vacuo to give the title compound as yellow oil (1.1 g, yield 68% ).1HNMR (400 MHz, CDCh) 8 (ppm): 4.64-4.46 (m, 2H), 2.79-2.67 (m, 1H), 1.29 (d, J= 7.1 Hz,3H).19F NMR (376 MHz, CDCh) 8 (ppm): -71.6, -74.5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-23-2, 3,3,3-Trifluoro-2-methylpropan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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