Synthetic Route of 813-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol, molecular formula is C5H9Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The product from the previous step (0.66 g, 1.25 mmol) was dissolved in dichloromethane (30 mL). Then 3-chloro-2,2-di(chloromethyl)propane-1-ol(0.24 g, 1.25 mmol) and DMAP (catalytic amount) were added. The reactantswere cooled to 0 C. EDAC (0.24 g, 1.25 mmol) was then added. The reactant was stirred at room temperature for 24h, and distilled under reduced pressure. The residue was purified by silica gel column chromatography (gradient elutionwith eluent: N-hexane/ethyl acetate) to give 3-chloro-2,2-di(chloromethyl)propyl 4-(2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenoxy] butyl)-4-oxo-2-acetamino-butyrate (0.57 g, yield 65%).
According to the analysis of related databases, 813-99-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd; Shanghai Synergy Pharmaceutical Sciences Co., Ltd; GE, Jian; LI, Yunfei; ZHANG, Zhen; WANG, Yijin; WANG, Jiamiao; CHENG, Tao; (57 pag.)EP3348548; (2018); A1;,
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