Reference of 59012-91-8, Adding some certain compound to certain chemical reactions, such as: 59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate,molecular formula is C12H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59012-91-8.
Compound M2. [00202] Compound Ml (see below; 7.79 g, 37.4 mmol) was dissolved in anhydrous THF (50 mL) containing N,N-diisopropylethylamine (8.14 mL, 46.8 mmol) under argon, and the resulting solution was chilled down to 0C in an ice-water bath. Diisopropylphosphoramidous dichloride (3.46 mL, 18.8 mmol) was added drop wise via syringe over a period of 5 minutes with stirring and cooling. The reaction mixture was allowed to warm up to room temperature and stirred overnight. Precipitated salts were removed by filtration, and the filtrate was concentrated in vacuum. The residue was dissolved in ethyl acetate (-150 mL) and washed with 5% NaHC03 (3 x 50 mL) followed by brine (50 mL). The organic layer was separated, dried over Na2S04, filtered and concentrated. The product (TLC: Rf -0.6 in ethyl acetate/hexanes/triethylamine (20:80:2)) was isolated using flash chromatography on silica gel column (4 x 20 cm) loading from hexanes/ triethylamine (100:2) and eluting with acetate/hexanes/ triethylamine (20:80:2). Pure fractions were pooled and concentrated to give 8.1 g (79%) of colorless oil. XH NMR (DMSO-d6): delta 7.37 (d, 4H, J=8.6 Hz), 7.07 (d, 4H, J=8.6 Hz), 4.76 – 4.63 (m, 4H), 3.70 – 3.61 (m, 2H), 1.30 (s, 18H), 1.16 (d, 12H, J=6.8 Hz). 31P NMR (DMSO-d6): delta 147.30.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 59012-91-8, 4-(Hydroxymethyl)phenyl pivalate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CEPHEID; GALL, Alexander A.; LOKHOV, Sergey G.; PODYMINOGIN, Mikhail A.; VIAZOVKINA, Ekaterina V.; LUND, Kevin Patrick; WO2015/153510; (2015); A1;,
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