Recommanded Product: (4-Methoxyphenyl)methanol. Guo, P; Wang, K; Jin, WJ; Xie, H; Qi, LL; Liu, XY; Shu, XZ in [Guo, Peng; Wang, Ke; Jin, Wen-Jie; Xie, Hao; Qi, Liangliang; Liu, Xue-Yuan; Shu, Xing-Zhong] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China published Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis in 2021, Cited 104. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.
Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.
Recommanded Product: (4-Methoxyphenyl)methanol. Welcome to talk about 105-13-5, If you have any questions, you can contact Guo, P; Wang, K; Jin, WJ; Xie, H; Qi, LL; Liu, XY; Shu, XZ or send Email.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts