Recently I am researching about SELECTIVE DEUTERATION; LABELED COMPOUNDS; DEOXYGENATION; DEUTERIUM; D2O; TRITIATION; EFFICIENT; FLUORINE; ALCOHOLS; ROUTE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21972094, 21672163]; Guangdong Special Support Program, Pengcheng Scholar program; Shenzhen Innovation Program [JCYJ20190808142001745]. Formula: C8H10O2. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Ou, W; Xiang, XD; Zou, R; Xu, Q; Loh, KP; Su, CL. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol
Site-specific incorporation of deuterium into drug molecules to study and improve their biological properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon-oxygen bonds in alcohols and ketones with D-2 balloon for practical synthesis of deuterated pharmaceuticals and chemicals with benzyl-site (sp(3) C-H) D-incorporation. The highlights of this deoxygenative deuteration strategy are mild conditions, broad scope, practicability and high chemoselectivity. To enable the direct use of D2O, electrocatalytic D2O-splitting is adapted to in situ supply D-2 on demand. With this system, the precise incorporation of deuterium in the metabolic position (benzyl-site) of ibuprofen is demonstrated in a sustainable and practical way with D2O.
Formula: C8H10O2. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts