With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, molecular weight is 117.1894, as common compound, the synthetic route is as follows.HPLC of Formula: C6H15NO
A mixture of 3-[6-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-4-(methylsulfonyl)pyridin-2-yl]prop anoic acid (0.21 g, 0.5 mmol), N,N-diethylethanolamine (0.12 g, 1.0 mmol), HOBt H2O (92 mg, 0.6 mmol), WSC (116 mg, 0.6 mmol), 4-dimethylaminopyridine (74 mg, 0.6 mmol) and DMF (3 ml) was stirred at room temperature for 18 hours. Water (20 ml) was added to the reaction mixture and the crystals formed were taken by filtration. The crystals were recrystallized from ethanol to give the title compound (0.13 g, 50%). Melting point: 150.5-151.5C 1H-NMR (CDCl3) delta: 1.02 (6H, t, J=7.2 Hz), 2.57 (4H, q, J=7.2 Hz), 2.71 (2H, t, J=6.3 Hz), 3.04 (2H, t, J=7.2 Hz), 3.16 (3H, s), 3.39 (2H, t, J=7.2 Hz), 4.20 (2H, t, J=6.3 Hz), 7.60-7.67 (2H, m), 7.98 (1H, s), 8.50 (1H, d, J=8.4 Hz), 8.80 (1H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-37-8, 2-(Diethylamino)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1897880; (2008); A1;,
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