An article Synthesis of functionalized pyrimidouracils by ruthenium-catalyzed oxidative insertion of (hetero)aryl methanols into N-uracil amidines WOS:000587048900001 published article about ONE-POT SYNTHESIS; HETEROCYCLIZATION SYNTHESIS; NITROGEN-HETEROCYCLES; 3-COMPONENT SYNTHESIS; PURINE DERIVATIVES; AEROBIC OXIDATION; EFFICIENT; ALCOHOLS; ALDEHYDES; 1,3,5-TRIAZINES in [Debnath, Pradip] Maharaja Bir Bikram Coll, Dept Chem, Agartala 799004, Tripura, India; [Sahu, Gouranga] Ramkrishna Mahavidyalaya, Dept Chem, Unakoti, India; [De, Utpal C.] Tripura Univ, Dept Chem, Agartala, India in 2021, Cited 96. Recommanded Product: (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5
A dehydrogenative coupling of N-uracil amidines with (hetero)aryl methanols has been developed, allowing for the facile synthesis of a broad range of structurally diverse pyrimidouracils. By applying [RuCl2(p-cymene)](2)/Cs2CO3 as an efficient catalytic system, the easily available, cheap (hetero)aryl methanols were firstly employed for oxidative insertion/C-H amination into the N-uracil amidines, providing highly functionalized pyrimido[4,5-d]pyrimidine-2,4-diones. Due to the better stability of alcohols than aldehydes, this synthetic protocol is applicable to a broad range of alcoholic substrates and does not required any protection during the whole preparation process. The presented protocol has the potential to prepare valuable products which cannot be accessed presently or extremely arduous to procure by following regular procedure. Hence, this is a remarkably improved protocol compared with the existing methodologies. The overall reaction sequence is an effective oxidation-imination-cyclization tandem process catalyzed by ruthenium catalyst.
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