An article Synthesis of the C1-C16 fragment of bryostatin for incorporation into 20,20-fluorinated analogues WOS:000599822100009 published article about ANTINEOPLASTIC AGENTS; DERIVATIVES; MACROLIDE; LEADS in [Mears, Paul R.; Thomas, Eric J.] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England in 2021, Cited 44. Safety of (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5
The stereoselective synthesis of a carboxylic acid ester corresponding to the C1 -C16 fragment of bryostatin, with 4-methoxybenzyl (PMB) protection for the 7-hydroxyl group, is reported. The key steps included a Horner-Wadsworth-Emmons reaction between (5R)-3-[ (E)-2-tri- isop ropyls ilyloxy ethylidene]-6-(4-methoxybenzyloxy)-5-triethylsilyloxyhexanal and dimethyl (4,5,6R,85)-10-hydroxy-6,8-di-O-isopropylidene 4 (4 methoxybenzyloxy)-3,3-dimethyl-2-oxodecan-1-yl phosphonate, that gave the corresponding (E)-alkene, followed by selective cleavage of the triethylsilyl ether and cyclisation to give the required 2,6-cis-disubstituted 4-[(Z)-tri-isopropylsilyloxyethylide]tetrahydropyran. Oxidation of the primary alcohol gave the corresponding carboxylic acid that was converted into the required allyl ester. (C) 2020 Elsevier Ltd. All rights reserved.
Safety of (4-Methoxyphenyl)methanol. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Mears, PR; Thomas, EJ or concate me.
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