Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropentan-1-ol
A solution of 5-chloro-l-pentanol (10 g, 80 mmol) in DMF (100 mL) at 0 0C was treated with imidazole (19 g, 185 mmol) and TBDPS-Cl (26 g, 95 mmol), and the mixture was stirred and allowed to warm to room temperature over 2 hours before being quenched with the addition of water and extracted with EtOAc. The organic extract was washed with aqueous IN HCl, saturated aqueous NaHCOs, saturated aqueous NaCl, dried (Na2SO4), concentrated under reduced pressure, and subjected to flash chromatography to give 5 -(t-butyldimethylsilyloxy)-l -chloropentane as a colorless liquid (11 g, 38percent).
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Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
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