In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 927-74-2, name is 3-Butyn-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Butyn-1-ol
Preparation 39 Methyl [4-(4-Hydroxybut-1-ynyl)phenyl]acetate To a stirred solution of the product of Preparation 38 (4.5 g, 16.3 mmol) in diethylamine (100 mL) was added but-3-yn-1-ol (1.9 mL, 32.6 mmol), Pd(PPh3)2Cl2 (500 mg, 1.63 mmol) and CuI (154 mg, 0.815 mmol) and resulting mixture was stirred for 17 h at room temperature. The solvent was then removed under reduced pressure and the residue was dissolved in diethyl ether (200 mL) and this solution was filtered to remove salts. The solvent was then removed under reduced pressure and the crude product was purified by silica gel chromatography (60% EtOAc/Hexane) to afford the title intermediate (3.03 g, 91% yield).
The synthetic route of 927-74-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mammen, Mathai; Dunham, Sarah; US2005/113417; (2005); A1;,
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