Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 117087-18-0, blongs to alcohols-buliding-blocks compound. Product Details of 117087-18-0
White powder obtained in the step (3) (75 g, 0.38 mol)Soluble in N,N-dimethylformamide (1L), ice bath,Nitrogen partial protection,One copy Sodium hydrogen(15.2g, 0.38mol, 60% in mineral oil),After stirring for 1 hour, methanesulfonyl chloride (43 g, 0.375 mol) was added dropwise.The system was allowed to warm to room temperature and stirring was continued for 2 hours.Then the system is cooled to 0 C,Add one part of sodium hydrogen (15.2g, 0.38mol),The system was slowly warmed to room temperature again and stirring was continued for 3 hours.In the ice bath, adding 1M means adjusting the pH to neutral.Add 2L of water, extract ethyl acetate 300mL 5 times,The organic phases were combined, washed 3 times with water, dried and concentrated.The residue was dissolved in methanol 500 mL.Add 100 mL to the methanol phase and stir for 20 minutes.Layered,Then the lower layer was continuously added with 100 mL of petroleum ether, stirred for another 20 min, layered, and the lower layer was concentrated, and ethyl acetate and petroleum ether were crystallized 1:10.Obtained 53 g of a white solid. Yield 78%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Xinyuan Pharmaceutical Technology Co., Ltd.; Chai Teng; Lin Zengming; (12 pag.)CN108314665; (2018); A;,
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