Related Products of 769-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.15, as common compound, the synthetic route is as follows.
A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2.0 g, 13.1 mmol) and 6i(lH-imidazol-l-yl)methanone (4.26 g, 26.2 mmol) in 20 mL CH2CI2 was heated overnight at 50 C The reaction was quenched with water and extracted with CH2CI2, and the combined layers were dried over MgS04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2C12 gave (benzo[d][l,3]dioxol-7-yl)methyl lNo.-imidazole-l-carboxylate (2.8 g, 86%). ltt NMR (400 MHz, CDC13) 8 8.15 (t, /= 0.9 Hz, 1H), 7.44 (t, J= 1.4 Hz, 1H), 7.07 (dd, J= 1.6, 0.8 Hz, 1H), 6.95 (m, 2H), 6.84 (m, 1H), 6.01 (s, 2H), 5.33 (s, 2H).
Statistics shows that 769-30-2 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-4-ylmethanol.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
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