In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Chloro-1-phenylpropan-1-ol
A. (1 -Bromo-3-chloropropyl)benzene; 3-Chloro-1 -phenyl-1 -propanol (1.71 g, 10 mmol) was dissolved in dry Et20 (27 ml_) and purged with N2. A solution of PBr3 (0.63 ml_, 6.6 mmol) in dry Et20 (27 mL) was added dropwise very slowly. The reaction was stirred for 2 h at room temperature, followed by washing with 5% aqueous sodium acetate (x2) and brine (x1 ). The organic fraction was dried (MgS04), filtered, and the solvent evaporated to dryness. The resulting crude mixture was purified by column chromatography (S1O2, hexane/EtOAc) to obtain the desired compound as a yellow oil in 45% yield (1 .06 g, 4.54 mmol).
The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PROUS INSTITUTE FOR BIOMEDICAL RESEARCH, S.A.; MUNOZ, Rosa; GARCIA-DELGADO, Noemi; FLORES, Ramon; SERRADELL, Neus; PROUS, Josep, R.; WO2012/13691; (2012); A1;,
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