Application of 617-94-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 617-94-7, name is 2-Phenyl-2-propanol. A new synthetic method of this compound is introduced below.
To sodium hydride (60% dispersion in mineral oil, 280 mg, 7.00 mmol, 0.5 equiv) in anhydrous diethyl ether (28 mL) was added freshly distilled 2-phenyl-2-propanol (4.20 g, 30.8 mmol, 2.2 equiv) at 0 C and the mixture was stirred for 1 h at room temperature. The reaction mixture was cooled to 0 C, 2,2,2-trichloroacetonitrile (2.80 mL, 28.0 mmol, 2.0 equiv) were added slowly and stirring was continued for 3 h at ambient temperature. The solvent was removed under reduced pressure and the residue re-dissolved in PE (7.0 mL), anhydrous MeOH (283 pL, 7.00 mmol, 0.5 equiv) was added and the solution was stirred for 10 min at room temperature. The mixture was filtered through a plug of Celite eluting with PE and the filtrate was concentrated in vacuo to give the crude imidate. To a suspension of Fmoc-Ala-OH (4.36 g, 14.0 mmol, 1.0 equiv) in CH CI (80 mL) was added a solution of the imidate in CH CI (15 mL) and the mixture was stirred for 16 h at room temperature. The reaction mixture was filtered through a plug of Celite eluting with CH CI , the solvent was removed in vacuo, and the residue was purified by column chromatograph (S O , PE/EtOAc 4:1) to give Fmoc-Ala-OCumyl (55) (6.00 g, 14.0 mmol, quant yield) contaminated with small amounts of 2-phenyl-2-propanol (~85:15 by 1H N MR) as a pale-yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,617-94-7, 2-Phenyl-2-propanol, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITY OF WARWICK; SHIPMAN, Michael; (96 pag.)WO2019/186174; (2019); A1;,
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