Reference of 115-20-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115-20-8 as follows.
Preparation of 12′- (2, 2,2-Trichloroethylcarbonyl) vinblastine Trifluoroacetate [00125] Carbon monoxide was bubbled through a solution of 12′- iodovinblastine (53 mg, 0.057 mmol), triethylamine (57 mg, 0.565 mmol) and bis (triphenylphosphine) palladium (II) dichloride (8 mg, 0.011 mmol) in a mixture of DMF/2,2, 2-trichloroethanol (2 mL, 1 : 1) for 5 min, then the reaction mixture was heated at 50 C for 9 h under one atmosphere of carbon monoxide (balloon). The solution was diluted with ethyl acetate (15 mL) then washed with saturated aqueous NaHC03 (2 x 5 mL) and brine (5 mL), dried over MgS04 and evaporated to dryness in vacuo. The residue was purified by reverse phase chromatography (C18, acetonitrile/water, 0.05% trifluoroacetic acid) to provide 12′- (2, 2,2- trichloroethylcarbonyl) vinblastine trifluoroacetate (33 mg, 48%) as a white powder after lyophilization
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115-20-8, its application will become more common.
Reference:
Patent; AMR TECHNOLOGY, INC.; WO2005/55939; (2005); A2;,
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