The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
[0382] N-Cyclohexyl N-Methyl-2E,6E,10E-Geranylgeranyl amine (17a): To a dry reaction flask equipped with stir bar, N2 in let was placed alcohol 1 (0.145g, 0.5 mmol), t riphenylphosphine (0.196g, 0.75 m mol) and N-methylcyclohexylam ine (0.065 m L, 0.5 m mol) in anhydrous THF (1 mL). The reaction was cooled to 0 C and to it was added DIAD (0.151 g, 0.75 m mol) drop wise and the resu lting reaction was stirred at room temperatu re for overnight (~16h). After quenching it with H20 (5 m L), it was extracted with DCM (2 x 10 m L), dried over anhydrous sodiu m su lfate and the solvent was removed under a reduced pressure. The resu lting residue was chromatographed over silica gel using n-hexane and then 2-5% EtOAc in n-hexane to afford the desired amine 17a, yield : 0.072g (38%). LCMS: MS (m/z): 408.4 (M+N a).
With the rapid development of chemical substances, we look forward to future research findings about 24034-73-9.
Reference:
Patent; COYOTE PHARMACEUTICALS, INC.; SERIZAWA, Hiroaki; ARGADE, Ankush B.; DATWANI, Akash; SPENCER, Natalie; PAN, Yonghua; ERMINI, Florian; WO2013/130654; (2013); A1;,
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