With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane, molecular formula is C5H10O2, molecular weight is 102.13, as common compound, the synthetic route is as follows.HPLC of Formula: C5H10O2
Into a solution of [l-(hydroxymethyl)cyclopropyl]methanol (9.5 g, 93.02 mmol,) and CC14 (15.57 g, 102.43 mmol) in THF (50 mL) at 0 C was added [bis(dimethylamino)phosphanyl]-dimethylamine (16.70 g, 102.33 mmol). The resulting solution was stirred overnight at room temperature and then quenched by the addition of water. The resulting solution was extracted with DCM and the organic layers combined. The resulting mixture was washed with sat. NaCl and dried over Na2S04 and then concentrated. The residue was purified by chromatography (EtO Ac/pet. ether (1 : 1) to afford 5.2 g (46%) of [1- (chloromethyl)cyclopropyl]methanol as yellow oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane, and friends who are interested can also refer to it.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth Albert; VERNER, Erik; (122 pag.)WO2016/191172; (2016); A1;,
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