Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 86770-74-3, blongs to alcohols-buliding-blocks compound. Product Details of 86770-74-3
Example 28 Synthesis of Compound 122 To the solution of intermediate carbonate 1B obtained in Example 11 (5.04 mumol, 5 mg) in DCM (7.77 mmol, 0.5 mL) was added 2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethan-1-ol (0.050 mmol, 9.75 mg) and Hunig’s base (0.050 mmol, 8.81 muL). The reaction mixture was stirred overnight at rt and the volatiles were removed. The crude material was purified by RP-column chromatography to afford Compound 122 (3.1 mg, 58.8%) as a white solid. Observed ESI HRMS: m/z 1045.6173 [M+H]+. The 1H NMR spectrum of Compound 122 is shown in FIG. 44.
The synthetic route of 86770-74-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sirenas LLC; MACHERLA, Venkat Rami Reddy; SCHAMMEL, Alexander Wayne; USUI, Ippei; STOUT, Elizabeth Paige; BEVERAGE, Jacob Neal; LEE, Bryan Junn; COHEN, Steven Bruce; (304 pag.)US2017/15710; (2017); A1;,
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