Synthetic Route of 431-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol, molecular formula is C3H6F3NO, molecular weight is 129.0811, as common compound, the synthetic route is as follows.
A mixture of propyl-(2,6, 8-trichloro-pyrimido [5 ,4-dj pyrimidin-4-yl)-amine(2) (250 mg, 0.85 mmol) and 3-amino-1,1,1-trifluoro-propan-2-ol (221 mg, 1.71 mmol) inTHF (7 mL) was stirred at room temperature for 1 8h. A saturated NaHCO3 solution (30 mL) was added, the resulting suspension was extracted with dichloromethane (3 x 10 mL). The combined organic extracts were washed with brine (30 mL) and dried over solid anhydrous Na2SO4. After filtering, the solvent was removed and the residue was purified by flashcolumn chromatography using gradient elution from PE/EtOAc (3:1) to PE/EtOAc (1:9) to give 3-(2,6-dichloro-8-propylamino-pyrimido[5,4-djpyrimidin-4-ylamino)-1 ,1,1 -trifluoropropan-2-ol (21) (277 mg, 84% yield). ESI-MS (m/z): 385, 387, 389 [M+Hf?.
Statistics shows that 431-38-9 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1,1,1-trifluoropropan-2-ol.
Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
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