Electric Literature of 23377-40-4, Adding some certain compound to certain chemical reactions, such as: 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol,molecular formula is C19H40O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23377-40-4.
Compound 2 (658 mg, 1.74 mmol) was added to the reaction flask.Add 10 ml of anhydrous dichloromethane to dissolve.Nitrogen protection drops to 0 C,Compound 1 (631 mg, 2.1 mmol) was slowly added dropwiseAnd pyridine (826 mg, 10.44 mmol)Anhydrous dichloromethane solution.After the addition, the reaction was carried out at a low temperature for 10 minutes, and then the reaction was continued to room temperature for 2 hours.MS monitors the reaction,The reaction was quenched by the addition of 1 M diluted hydrochloric acid (10 mL).Stir at room temperature overnight,After MS monitors the reaction, the organic phase is separated.The aqueous phase was extracted 2-3 times with dichloromethane.Combine the organic phase,Washed with saturated saline,Concentration and purification by silica gel column chromatography gave 815.3 g of product, yield: 82.3%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 23377-40-4, 3-(Hexadecyloxy)propan-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (46 pag.)CN109485676; (2019); A;,
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