Reference of 41175-50-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 15.0 mL anhydrous DMF was added dropwise POCl3 (0.9 mL, 9.2 mmol) under an atmosphere of argon at 0 C. The mixture was stirred at 0 C for 1h. A solution of compound 7 (1.6 g, 7.6 mmol) in anhydrous DMF (5.0 mL) was added in portions and then the reaction was allowed to be stirred at 0 C to room temperature for 32 h. Saturated salt solution (25 mL) was added and the reaction mixture extracted with EA. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The crude product was purified by column chromatography (PE:EA, 10:1) as a brown powder compound 8 (1.3 g, yield: 78.8%). 1H NMR (400 MHz, CDCl3), delta ppm: 9.42 (s, 1H), 7.30 (s, 1H), 6.89 (s, 1H), 3.33-3.32 (m, 4H), 2.72 (s, 4H), 1.98 (s, 4H); HRMS (ESI) calcd. for C13H16N1O2 [M+H]+: 218.1776, found 218.1208.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol.
Reference:
Article; Afzal, Muhammad Wasim; Chen, Xi; Gao, Ying; Guo, Yuan; James, Tony D.; Tang, Haoyang; Teng, Hao; Tian, Jingye; Zhang, Yanhui; Chinese Chemical Letters; (2020);,
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