Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of (2-bromo-5-fluorophenyl) methanol (5g, 0.02 mol) in 1,4-dioxane (60 mL), bis(pinacolato)diboron (5.6 g, 0.022 mol) and potassium acetate (5.6 g, 0.06 mol) were added. The resulting mixture was degassed using a stream of nitrogen and to this was added [U’-bis(diphenylphosphino) ferrocene]dichloropalladium(ll) (250 mg, 0.34 mmol). The reaction mixture was then heated at 80 °C for 10 hrs. The mixture was cooled to room temperature, diluted with H20 and extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated in vacuum to yield (5-fluoro-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)methanol (5) that was used in the next reaction step without further purification. Yield-95percent; Purity-99.9percent.
According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; NANDA KUMAR, Mecheril Valsan; PITTA, Bhaskar Reddy; RANGISETTY, Jagadeesh Babu; (55 pag.)WO2017/183043; (2017); A1;,
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