Reference of 14002-80-3 ,Some common heterocyclic compound, 14002-80-3, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Sodium hydride (60 % wt in oil) (6.28 g, mmol) was added to a stirred solution of methyl 3 -hydroxy -2,2- dimethylpropanoate (10. 40 g, 78.69 mmol) in DMF 20 ml at 0 C, after 5 min l-bromo-2- methoxyethane (10.94 g, 78.69 mmol) was added dropwise, and the reaction mixture was allowed to stir for 3h. The reaction was quenched with cold saturated H4C1 (aq.) (30 mL), the aqueous layer extracted with DCM (2 x 50 mL), and the combined organic layers dried over Na2S04. After removing the solvent, the compound was purified by ESCO flash chromatography using heptane/ethyl acetate as eluent to yield 33% of product (5.0 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14002-80-3, its application will become more common.
Reference:
Patent; PROMEGA CORPORATION; ZHOU, Wenhui; BINKOWSKI, Brock; MEISENHEIMER, Poncho; NILES, Andrew, L.; KUPCHO, Kevin; UNCH, James; (86 pag.)WO2019/10094; (2019); A1;,
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