In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 111-46-6, name is 2,2′-Oxybis(ethan-1-ol), the common compound, a new synthetic route is introduced below. SDS of cas: 111-46-6
Into a round-bottom flask (RBF) charged with argon and cooled to 0 C, 95 % NaH (1.64 g, 65 mmol) was suspended in anhydrous THF. Di(ethylene)glycol (9.5 mL, 100 mmol) was added dropwise. After 30 min of stirring at 0 oC, propargyl bromide (5.5 mL, 50 mmol, 80 % in toluene) was added slowly. The reaction was kept at 0 oC for another 2 h, then allowed to warm to RT overnight. The reaction was slowly quenched with water (30 mL) and the compound was extracted into CH2Cl2 (3 x 50 mL). The organic portions were combined and washed with H2O (1 x 30 mL), dried over Na2SO4, and concentrated in vacuo. Flash chromatography on a silica column (3:2 ethyl acetate:hexanes ) afforded alkyne 7 (3.66 g, 51 %) as a yellow oil. 1H NMR (CDCl3): delta 2.43 (t, 1H, J = 2.4Hz); 2.84-2.88 (br s, 1H), 3.58 (dt, 2H, J = 4.6Hz, 5.3Hz); 3.76-3.63 (m, 6H); 4.18 (d, 2H, J = 2.8Hz). 13C NMR (CDCl3): delta 58.5 [CH2]; 61.8 [CH2]; 69.2 [CH2]; 70.3 [CH2]; 72.7 [CH2]; 74.9 [CH]; 79.6 [C]. HRMS (ESI+) calcd. for C7H12O3Na [M++Na]: 167.0684. Found: 167.0680.
The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Inkster, James; Lin, Kuo-Shyan; Ait-Mohand, Samia; Gosselin, Simon; Benard, Francois; Guerin, Brigitte; Pourghiasian, Maral; Ruth, Thomas; Schaffer, Paul; Storr, Tim; Bioorganic and Medicinal Chemistry Letters; vol. 23; 13; (2013); p. 3920 – 3926;,
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