Reference of 33420-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33420-52-9, name is 2,2-Difluoropropan-1-ol, molecular formula is C3H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
7-[ 1 -(tert-butoxycarbonyl)piperidin-4-yl] -2-methyl-5-oxo-4,5-dihydropyrazolo[ 1 ,5-a]pyrimidine-3- carboxylic acid (100 mg, 266 muiotaetaomicron) was dissolved in tetrahydrofurane (5.0 ml, 62 mmol) and Nu,Nu’- Carbonyldiimidazole (86.2 mg, 531 muiotaetaomicron) was added. The mixture was heated at reflux for 1.5 h. Solvents were removed and 2,2-difluoropropan-l-ol (3.01 g, 31.4 mmol) was added. The mixture was heated at reflux for 18h and then purified by preparative HPLC (Method: column: Reprosil CI 8; 10 muiotaeta; 125×30 mm / flow: 50 ml/min / solvents: A = water (0,01% formic acid), B = acetonitrile / gradient: 0.00-5.00 min = 10%B, 6.50min = 20%B, 17.0-19.75min = 100%B, 19.75.00-23.00min = 90%B). Evaporation of the combined product fractions yielded the title compound (105 mg, 99 % purity, 86 % of theory). LC-MS (Method 1 IB): Rt = 2.03 min; MS (ESIneg): m/z = 453 [M-H]
According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ELLERMANN, Manuel; VALOT, Gaelle; CANCHO GRANDE, Yolanda; HAssFELD, Jorma; KINZEL, Tom; KOeBBERLING, Johannes; BEYER, Kristin; ROeHRIG, Susanne; SPERZEL, Michael; STAMPFUss, Jan; MEYER, Imke; KOeLLNBERGER, Maria; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; HEIERMANN, Joerg; HENGEVELD, Willem Jan; (764 pag.)WO2016/71216; (2016); A1;,
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