Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1202577-61-4, name is trans-(4-(Trifluoromethyl)cyclohexyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
General procedure: PPh3 (30.75 g, 117.4 mmol) was added slowly to a 0 C solution of (trans-4- (trifluoromethyl)cyclohexyl)methanol (17.8 g, 97.8 mmol) and CBr4 (38.85 g, 117.4 mmol) in dry DCM (200 mL). The reaction was stirred at room temperature overnight and then concentrated. Hexane/EtOAc (9/1, 300 ml) was added and the mixture was stirred for 1 hour and then filtered. The filtrate was concentrated and distilled under vacuum to give trans- 1 – (bromomethyl)-4-(trifluoromethyl)cyclohexane. XH NMR (300 MHz, CDC13): delta 3.30-3.28 (d, 2H), 2.02-1.92 (m, 5H), 1.70-1.59 (m, 1H), 1.40-1.27 (m, 2H), 1.13-1.00 (m, 2H)
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Reference:
Patent; MERCK SHARP & DOHME CORP.; CHRISTOPHER, Matthew, P.; FRADERA LLINAS, Francesc Xavier; MACHACEK, Michelle; MARTINEZ, Michelle; REUTERSHAN, Michael Hale; SHIZUKA, Manami; SUN, Binyuan; THOMPSON, Christopher Francis; TROTTER, B. Wesley; VOSS, Matthew, E.; YANG, Liping; WO2014/123882; (2014); A1;,
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