Synthetic Route of 100-37-8 , The common heterocyclic compound, 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
alpha-methyl-4-(2-thienylcarbonyl)benzene acetyl chloride 28.1g (0.1mol) was dissolved in chloroform 100ml . The mixture was cooled to 0. Triethylamine 15ml and diethylaminoethanol 11.7g (0.1mol) were added to the reaction mixture. The mixture was stirred for 3 hours at room temperature. The solvent was evaporated. The residue was dissolved in methanol (300ml), and 5% sodium bicarbonate (200ml) was added to the reaction mixture. The mixture was stirred for 3 hours. The mixture was evaporated and dried. methanol (300 ml) was added to the residue with stirring. The solid was removed by filtration, and washed with methanol. The solution was evaporated to dryness, and the residue was dissolved in chloroform (200ml). acetic acid 6g was added to the reaction mixture with stirring. Some of the solid matters were removed by filtration. another acetic acid 6g was added to the reaction mixture while Stirring. The organic solution was evaporated. After drying, the desired product 35g (83.2%) was obtained.
The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Techfields Biochem Company Limited; Yu, Chauncy; Shu, Rina; (52 pag.)JP2016/130241; (2016); A;,
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