Application of 534-03-2 ,Some common heterocyclic compound, 534-03-2, molecular formula is C3H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To serinol (10.40g, 114mmol) and sodium carbonate (42.30g, 399mmol) was added water (200mL), was added triphosgene (20.00g, 70mmol). Stirred for 12 hours at room temperature. After completion of the reaction, water (200 mL), dichloromethane (120mL × 3) extracted together The organic phase was washed with saturated brine (150 mL) and washed. Filtered and thesolvent evaporated under reduced pressure and the crude product purified by column chromatography (ethyl acetate / methanol(v / v) = 10/1) to give a colorless oil (5.2g, 39%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,534-03-2, its application will become more common.
Reference:
Patent; GUANGDONG HEC PHARMACEUTICAL CO., LTD; ZUO, YINGLIN; LAO, JINHUA; ZHENG, JINFU; WEN, LIANG; ZHANG, JIN; WU, SHOUTAO; YUAN, XIAOFENG; WANG, XIAOJUN; ZHANG, YINGJUN; (32 pag.)CN104497008; (2016); B;,
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