Synthetic Route of 39590-81-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane. A new synthetic method of this compound is introduced below.
Method A, Step 1To a solution of i-hydroxymethylcyclopropylmethanol AA1 (10 g, 98 mmol) in DMF (300 ml_) was added tert-butylchlorodiphenylsilane (26.3 ml_, 100 mmol) followed by diisopropylethylarnine (170 mL) and the reaction was stirred at RT overnight. The final mixture was quenched with water and extracted with EtOAc. The organic layer was washed with 3N HCI, sat NaHCO3, brine, dried over Na2SO4 and concentrated. The residue was purified by chromatography over silica gel (eluted with DCM/MeOH 100:0 to 80:20) to give 18.5 g (55%) of product AA2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2009/61699; (2009); A1;,
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