Adding a certain compound to certain chemical reactions, such as: 86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C8H19NO4, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H19NO4
A solution of 3 (100 mg, 0.116 mmol) in chlorobenzene (5.0 mL) was added to the mixture of 42 (67.4mg, 0.349 mmol) and triethylamine (35.3 mg, 0.349 mmol), and the mixture was stirred at roomtemperature. After18 h, the reaction mixture was evaporated to dryness. The residue was purified bycolumn chromatography (silica gel; CHCl3/MeOH = 25/1) and dried in vacuo to give 5 as a blackishsolid (24.1 mg, 23.8 %). Rf = 0.35 (CHCl3/MeOH, 10:1). 1H NMR (400 MHz, CDCl3, delta): 8.95 (s, -CH2NHCO-, 2H), 3.86-3.54 (m, HO-CH2CH2-, -CH2CH2NHCO-, 32H), 1.93 (br, HO-CH2CH2-, 2H),13C NMR (100 MHz, CDCl3): delta (ppm) = 163.0, 146.0, 145.3, 144.7, 144.4, 143.9, 143.1, 143.0, 142.4,142.3, 140.8, 138.0, 74.5, 72.7, 70.7, 70.5, 70.3, 70.1, 61.8, 59.8, 40.6. IR (KBr, cm-1): 3263, 2860,1653, 1543. UV (DMSO) lambdamax, nm (epsilon × 10-3, M-1cm-1): 265 (10), 330 (4.0).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,86770-74-3, 2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Narumi, Atsushi; Nakazawa, Tatsufumi; Shinohara, Kosuke; Kato, Hiroki; Iwaki, Yoshinori; Okimoto, Haruya; Kikuchi, Moriya; Kawaguchi, Seigou; Hino, Shodai; Ikeda, Atsushi; Shaykoon, Montaser Shaykoon Ahmed; Shen, Xiande; Duan, Qian; Kakuchi, Toyoji; Yasuhara, Kazuma; Nomoto, Akihiro; Mikata, Yuji; Yano, Shigenobu; Chemistry Letters; vol. 48; 10; (2019); p. 1209 – 1211;,
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