Extracurricular laboratory: Synthetic route of 162358-05-6

Statistics shows that 162358-05-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-Octylphenyl)ethanol.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. 162358-05-6

4-Octylphenethyl Methanesulfonate (Scheme 4). To a solution of 4-octylphenethyl alcohol (200 mg, 0.853 mmol) and triethylamine (1.19 mL, 8.53 mmol) in CH2C12 (8 mL) at 0 C was added methanesulfonyl chloride (0.33 mL, 4.27 mmol). After being stirred at rt for 5 h, the reaction mixture was evaporated, diluted with water, and the product was extracted with EtOAc. The extract was washed with brine, dried, and evaporated. Purification by silica gel chromatography, eluting with hexanes/EtOAc (5: 1), gave 253 mg (95%) of the mesylate as a yellow liquid; 1H NMR (400 MHz, CDC13) delta 0.87 (t, J = 6.9 Hz, 3H), 1.26- 1.30 (m, 10H), 1.58 (m, 2H), 2.57 (t, = 7.7 Hz, 2H), 2.83 (s, 3H), 3.02 (t, = 7.0 Hz, 2H), 4.40 (t, = 7.0 Hz, 2H), 7.14 (s, 4H); 13C NMR (100 MHz, CDC13) delta 14.1, 22.7, 29.3 (2C), 29.5, 31.6, 31.9, 35.3, 35.6, 37.3, 70.6, 128.8, 128.9, 133.4, 141.9; ESI-HRMS (M + Na)+ mlz calcd for Ci7H28Na03S 335.1657, found 335.1655.

Statistics shows that 162358-05-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-Octylphenyl)ethanol.

Reference:
Patent; RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK; UNIVERSITY OF STRATHCLYDE; BITTMAN, Robert; PYNE, Nigel J.; PYNE, Susan; BAEK, Dong Jae; LIU, Zheng; BYUN, Hoe Sup; WO2014/118556; (2014); A2;,
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