Application of 39590-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39590-81-3 as follows.
[1-(Hydroxymethyl)cyclopropyl]methanol obtained from Step A (0.2 g, 1.96 mmol), 4-bromo-2,6-difluoro-phenol (0.314 g, 1.5 mmol) and triphenylphosphine (0.393 g, 1.5 mmol) were dissloved in 24 mL of THF. Diisopropyl azocarboxylate (0.3 mL, 1.5 mmol) was added thereto, and the reaction mixture was stirred for 16 hours at room temperature. The mixture was concentrated under reduced pressure and purified by column chromatography to obtain the title compound (0.307 g, 70 %). 1H NMR (CDCl) delta 7.08 (2H, m), 4.08 (2H, s), 3.68 (2H, d), 1.84 (1H, t, OH), 0.62 (4H, m)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.
Reference:
Patent; LG LIFE SCIENCES LTD.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; WO2014/209034; (2014); A1;,
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