With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107859-98-3, name is Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.name: Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate
Example 3 Ethyl 3-[4-(bromomethyl)phenyl]propanoate Carbon tetrabromide (1.27 g) and triphenylphosphine (805 mg) were added to a methylene chloride solution (5 mL) of the compound (533 mg) as produced in Example 2, followed by stirring at room temperature for 30 min. An aqueous saturated sodium hydrogencarbonate solution was added to the reaction mixture, and extraction was effected with ethyl acetate. The organic layer was washed with an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified on a silica gel column chromatography (n-hexane:ethyl acetate = 9:1) to give the subject title compound (667 mg) showing the following physico-chemical values: TLC: Rf 0.61 (n-hexane:ethyl acetate = 4:1); 1H-NMR (CDCl3): d 1.23, 2.61, 2.94, 4.13, 4.48, 7.18, 7.32.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,107859-98-3, Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, and friends who are interested can also refer to it.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1785421; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts