Synthetic Route of 617-94-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.
General procedure: The alcohol (2mmol) and the anhydride (2.2mmol) were mixed in a 10mL test tube and 1mol% of salt A (0.02mmol) was added. The tube was then capped (or under N2 purge) and the reaction mixture was stirred at room temperature (except for 1-methylcyclopentanol at 60C). After a couple of hours the acid effluent was evaporated in vacuum. The residue was then allowed to cool to room temperature and the salt was precipitated by adding 2mL hexane (or toluene). After filtration, salt was recovered, and then evaporating solvent from the filtrate afforded the crude ester product. The recovered salt was charged with the substrates, and the reaction mixture was then proceeded to the next run. The products were quantified with GC analysis by comparison to NMP as an internal standard. The products from the 1st run were further purified by column chromatography, and the isolated yields were compared with the GC/MS yields. They were all in good agreement.
Statistics shows that 617-94-7 is playing an increasingly important role. we look forward to future research findings about 2-Phenyl-2-propanol.
Reference:
Article; Lu, Norman; Chang, Wei-Hsuan; Wei, Rong-Jyun; Fang, Yung-Cheng; Han, Tu-Wen; Wang, Guo-Quan; Chang, Jia-Yaw; Wen, Yuh-Sheng; Liu, Ling-Kang; Tetrahedron; vol. 72; 24; (2016); p. 3468 – 3476;,
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