Electric Literature of 6153-05-5, Adding some certain compound to certain chemical reactions, such as: 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol,molecular formula is C6H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6153-05-5.
n-BuLi (4.2 mL, 10 mmol, 2.4 mol/L) was added dropwise to a solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.48 g, 5 mmol) in THF (10 mL) at ?78 °C under a N2 atmosphere, and then the mixturewas stirred for 1 h at ?78 °C. A solution of 4g (0.94 g, 5 mmol) in THF (5 mL) was added slowly, themixture was stirred for 0.5 h at ?78 °C, and then it was warmed to room temperature and stirred for 2 h.The reaction was quenched with saturated aqueous NH4Cl solution (10 mL) and extracted with EtOAc(3 × 30 mL). The combined organics were washed with brine (2 × 20 mL), dried over anhydrousNa2SO4 and concentrated. The residue was purified by silica gel column chromatography (petroleumether/EtOAc, 1:2) to afford 6c (1.35 g, 95percent) as a yellow oil.
According to the analysis of related databases, 6153-05-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Han, Xiaoqiang; Wan, Chuan; Yang, Dongyan; Yuan, Xiaoyong; Du, Shijie; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 18; 9; (2013); p. 10776 – 10788;,
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