Electric Literature of 41175-50-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, molecular weight is 189.2536, as common compound, the synthetic route is as follows.
A mixture of 8-hydroxyjulolidine (300 mg, 1.59 mmol) and ethyl 4-chloroacetoacetate (260 ul, 1.90 mmol) was stirred at ?90 C. under argon atmosphere. To this mixture was added a solution of aluminum chloride (420 mg, 3.2 mmol) in nitrobenzene (5 ml) and the whole reaction mixture was stirred at ?130 C. for 3 hours. After the reaction mixture was cooled to room temperature, it was purified by column chromatography over silica gel eluting first with 5% ethyl acetate in hexane and then with chloroform to obtain the desired product as a yellow-brown solid (200 mg, 43% yield). TLC: Rf=0.56 (silica gel, 1:1 hexane/ethyl acetate). 1NMR (DMSO-d6): chemical shift (ppm) 7.21 (s, 1H, ArH), 6.15 (s, 1H, ArH), 4.86 (s, 2H, CH2), 3.28-3.25 (m, 4H, CH2), 2.76-2.69 (m, 4H, CH2), 1.90-1.87 (m, 4H, CH2). absorption maximum: 405 nm in methanol, emission maximum: 493 nm in methanol. MS: m/e 290.20.
The chemical industry reduces the impact on the environment during synthesis 41175-50-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Life Technologies Corporation; Kang, Hee Chol; Gee, Kyle; Johnson, Iain; Janes, Michael; US8981100; (2015); B2;,
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