Synthetic Route of 5333-42-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-octyl-1-dodecanol (5.88 g, 19.7 mmol), triphenylphosphine (6.20 g, 23.6 mmol) and imidazole (1.61g, 23.6 mmol) in CH2Cl2 (40 mL) was slowly added bromine (3.78 g, 10.4 mmol) at 0 C, and the mixture was stirred at room temperature for 24 h. The reaction was then quenched with 3% Na2S2O3 aq. The product was extracted withhexane, and then the hexane layer was washed with brine. After drying the solution over MgSO4 followed by filtration,the filtrate was condensed under the reduced pressure. The crude product was purified by silica gel columnchromatography using hexane/CH2Cl2 (1/1, v/v) as an eluent to afford 1 as transparent oil (5.80 g, 82%). 1H NMR (300MHz, CDCl3, delta, ppm, 25 C): 3.44 (d, J=3.9 Hz, 2H, Br-CH2-CH), 1.64-1.53 (m, 1H, Br-CH2-CH), 1.44-1.17 (m,32H, -CH2-), 0.88 (t, J=5.1 Hz, 6H, -CH3). 13C NMR (75 MHz, CDCl3, delta, ppm, 25 C): 39.89, 39.65, 32.72-26.72(14 carbons), 22.86 (2 carbons), 14.28 (2 carbons). IR (NaCl), v (cm-1): 2924 (alkyl C-H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5333-42-6, 2-octyldodecan-1-ol.
Reference:
Article; Aoyagi, Koutarou; Shoji, Yu; Otsubo, Saika; Kawauchi, Susumu; Ueda, Mitsuru; Matsumoto, Hidetoshi; Higashihara, Tomoya; Bulletin of the Chemical Society of Japan; vol. 87; 10; (2014); p. 1083 – 1093;,
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