Related Products of 722-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 722-92-9, name is 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, molecular formula is C9H7F6NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-(4-aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (10.0 g, 38.6 mmol) in DMF (50 mL) was dropwise added a solution of sodium nitrite (2.8 g, 40.5 mmol) in water (15.5 mL) and a 6M solution of hydrochloric acid (19.3 mL, 115.7 mmol), while maintaining the reaction temperature at 0?5 C. The reaction mixture was stirred for 30 min, and then potassium iodide (6.4 g, 38.6 mmol) was added portionwise at 0?5 C. The resulting reaction mixture was stirred overnight at rt. The reaction mixture was extracted with EtOAc, and the combined organic layers were washed with saturated sodium thiosulphate and dried over Na2SO4. The solvent was evaporated in vacuo to obtain the crude, which was purified by flash chromatography on silica gel (?5% EtOAc/Hex) to obtain the title compound.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 722-92-9, 2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol.
Reference:
Patent; The Scripps Research Institute; Kamenecka, Theodore Mark; Griffin, Patrick R.; Shin, Youseung; He, Yuanjun; Blayo, Anne-Laure; Lyda, Brent R.; Koenig, Marcel; Kumar, Naresh; Burris, Thomas; (119 pag.)US9586928; (2017); B2;,
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