Adding a certain compound to certain chemical reactions, such as: 6214-44-4, (4-Ethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H12O2, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H12O2
Reference Example 026 Preparation of Compound 46 (0606) (0607) Dibenzo-18-crown-6 (0.152 mg, 11.8 mmol) and potassium hydroxide (1.14 g, 20.3 mmol) were added to the toluene solution (30 mL) of Compound 38 (2.0 g, 8.44 mmol) and 4-ethoxybenzylalcohol (1.80 g, 11.8 mmol), and the mixture was stirred at 120 C. for 2 hours. Water was added to the mixture, and the mixture was extracted with chloroform. The organic layer was dried over magnesium sulfate. The solvent was condensed under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate-hexane) to afford Compound 46 (2.42 g, yield 93%). (0608) 1H-NMR (CDCl3) delta: 8.20 (d, J=2.4 Hz, 1H), 7.62 (dd, J=8.8, 2.5 Hz, 1H), 7.38-7.32 (m, 2H), 6.91-6.86 (m, 2H), 6.68 (d, J=8.7 Hz, 1H), 5.25 (s, 2H), 4.03 (q, J=7.0 Hz, 2H), 1.41 (t, J=7.0 Hz, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6214-44-4, (4-Ethoxyphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; SHIONOGI & CO., LTD.; Matsumura, Akira; Kobayashi, Naotake; Nishiura, Yuji; Tagashira, Sachie; Kida, Shiro; Kurahashi, Kana; Yonehara, Mitsuhiro; US2015/246938; (2015); A1;,
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