Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5333-42-6, name is 2-octyldodecan-1-ol. A new synthetic method of this compound is introduced below., COA of Formula: C20H42O
2-octyldodecyl thiophene-3-carboxylate (SI). A solution of thiophene-3-carboxylic acid (1, 5.126 g, 40 mmol) in 150 mL DCM was stirred at room temperature under N2. Then 4-Dimethylaminopyridine (1.466 g, 12 mmol), a DCM solution of Nu,Nu’-dicyclohexylcarbodiimide ( 9904 mg , 48 mmol ) and 2-octyldodecan-l-ol (2, 23.88 g, 80 mmol ) were added to the system. The reaction mixture was stirred for another 12 hours. 50 mL distilled water was added and the reaction mixture was filtered, diluted with hexane and washed with water and brine. The organic layer was dried over Na2S04, filtered and concentrated. Then the residue was purified with silica gel chromatography to provide pure product as transparent liquid (17.25 g, 92% yield). 1H NMR (400 MHz, CDC13) delta 8.08 (d, / = 1.7 Hz, 1H), 7.54 – 7.51 (m, 1H), 7.31 – 7.28 (m, 1H), 4.18 (d, / = 5.6 Hz, 2H), 1.74 (d, / = 4.4 Hz, 1H), 1.41 – 1.22 (m, 32H), 0.88 (t, / = 6.3 Hz, 6H). 13C NMR (101 MHz, CDC13) delta 163.13, 134.27, 132.57, 128.09, 126.07, 67.68, 37.63, 32.12, 32.11, 31.64, 30.15, 29.85, 29.80, 29.76, 29.55, 29.51, 26.96, 22.89, 22.88, 14.31. HRMS (MALDI+) Calcd for C25H4402S (M+): 408.3062, Found: 408.3080.
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Reference:
Patent; THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY; YAN, He; LIU, Jing; (52 pag.)WO2017/223407; (2017); A1;,
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