Reference of 10029-04-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, molecular formula is C6H10O3, molecular weight is 130.14, as common compound, the synthetic route is as follows.
Lithium hydroxide monohydrate (145 mg, 3.46 mmol, 5.0 eq.) was added to a solution of ethyl 2-(hydroxymethyl)acrylate (90 mg, 0.69 mmol, 1.0 eq.) in tetrahydrofuran/methanol/water (3 mL, 1/1/1, v/v/v). The reaction was stirred at room temperature for 14 hours, and concentrated. The residue was dissolved in water (10 mL), adjusted with 2 N HCl to pH=5, and then extracted with ethyl acetate (20 mL*3). The combined organic phases were dried over anhydrous sodium sulfate, and concentrated to give the title compound (70 mg, yield: 100%).
Statistics shows that 10029-04-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(hydroxymethyl)acrylate.
Reference:
Patent; Zhejiang DTRM Biopharma Co. Ltd.; He, Wei; (167 pag.)US2016/200730; (2016); A1;,
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