The important role of (4-Vinylphenyl)methanol

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-61-9, (4-Vinylphenyl)methanol, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1074-61-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 1074-61-9

Step A 1-Bromomethyl-4-vinyl-benzene Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-61-9, (4-Vinylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US6344485; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts