Reference of 10029-04-6 ,Some common heterocyclic compound, 10029-04-6, molecular formula is C6H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
1.0 g (7.7 mmol) hydroxymethyl acrylate was dissolved in 1.5 mol 5 weight-% sodium hydroxide solution (0.46 g; 11.6 mmol NaOH) and stirred for 4 hours at room temperature. After several extractions with diethyl ether, the ether phase was washed with water, dried over calcium chloride and the product was dried in vacuum. Yield: 0.47 g (60%) 1H-NMR [ppm]: delta (500 MHz, CDCl3)=3.2 (HO-CH2); 4.2 (HO-CH2); 5.85 (=CH2); 6.25 (=CH2); 12.5 (O=C-OH)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 10029-04-6, Ethyl 2-(hydroxymethyl)acrylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DENTSPLY International Inc.; KLEE, JOACHIM E; RITTER, HELMUT; POHLE, SVEN; ELSNER, OLIVER; BARDTS, MAREIKE; US2015/238390; (2015); A1;,
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